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İnfertilite ve Mikro Besin Ögeleri

Year 2021, Volume: 7 Issue: 1, 1 - 13, 01.02.2021

Rana Nagihan Akder Nurcan Yabancı Ayhan

Abstract

İnfertilite düzenli cinsel ilişkiye ve hiçbir korunma yöntemi kullanılmamasına rağmen bir sene içerisinde gebelik gerçekleşmeme durumu olarak tanımlanmaktadır. İnfertilite tüm dünyayı etkileyen önemli bir sağlık sorunudur. İnfertilitenin önlenmesinde ve tedavisinde yeterli ve dengeli beslenme büyük önem taşımaktadır. Enerji dengesi, beden kütle indeksi ve makro besin ögelerinin infertilite üzerinde etkileri bulunduğu aşikardır. Bu derleme makalenin amacı ise mikro besin ögelerinin infertilite üzerindeki etkilerini bilimsel veriler ışığıyla aydınlatmaktır. Antioksidan özellikteki mikro besin ögelerinin (A, C, E vitaminleri, selenyum ve çinko gibi) DNA hasarının önlenmesi, serbest radikallerin yok edilmesi aracılığıyla infertilitede etkili olduğu düşünülmektedir. Folat, D vitamini ve B12 vitaminin genitoüriner sistem etkileri sayesinde infertilitenin önlenmesi ve tedavisinde etkin olabileceği belirtilmiştir. Mikrobesin ögeleri ile infertilite arasındaki ilişkinin tam olarak açıklanması, suplemanların kullanım dozları ve sağlık yararlarının incelenmesi amacıyla yapılacak çalışmalara ihtiyaç duyulmaktadır.

Keywords

infertilite mikro besin ögeleri antioksidanlar

References

  • Akalın, H., & Eryılmaz, G. (2017). Beslenmenin Üreme Sağlığına Etkisi. Turkiye Klinikleri Journal of Obstetric-Women's Health and Diseases Nursing-Special Topics, 3(3), 185-192.
  • Avşar, A. F. Y., Taş, E. E., & Akçay, G. Y. (2013). B-12 vitamini ve infertilite. Ankara Medical Journal, 13(2).
  • Balercia, G., Buldreghini, E., Vignini, A., Tiano, L., Paggi, F., Amoroso, S., . . . Littarru, G. (2009). Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertility and sterility, 91(5), 1785-1792.
  • Bayer, S. R., & Alper, M. M. (2007). Boston IVF Handbook of Infertility: A Practical Guide for Practitioners Who Care for Infertile Couples: CRC Press.
  • Berridge, M. J. (2017). Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). American Journal of Physiology-Cell Physiology, 314(2), C135-C151.
  • Buhling, K. J., Schumacher, A., zu Eulenburg, C., & Laakmann, E. (2019). Influence of oral vitamin and mineral supplementation on male infertility: a meta-analysis and systematic review. Reproductive biomedicine online.
  • Cecchino, G. N., Seli, E., da Motta, E. L. A., & Velasco, J. A. G. (2018). The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights. Reproductive biomedicine online.
  • Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A., & Willett, W. C. (2008). Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility. Fertility and sterility, 89(3), 668-676.
  • Chen, W., Jiao, X., Zhang, J., Wang, L., & Yu, X. (2018). Vitamin D deficiency and high serum IL-6 concentration as risk factors for tubal factor infertility in Chinese women. Nutrition, 49, 24-31. doi:10.1016/j.nut.2017.11.016
  • Çağıran-Yılmaz, F., & Yardımcı, H. (2015). Beden Kütle İndeksinin İnfertilite Üzerine Etkisi. Hacettepe University Faculty of Health Sciences Journal, 1, 1-6.
  • Çayan, S., Özdemir, U. D. A., Orhan, İ., Altay, B., & Kadıoğlu, A. (2015). Oksidatif stresin fertilitiye etkisi ve infertil erkeklerde anti-oksidan tedavinin yeri. Androloji Bülteni, 17, 118-124.
  • da Silva, T. M., Maia, M. C. S., Arruda, J. T., Approbato, F. C., Mendonça, C. R., & Approbato, M. S. (2013). Folic acid does not improve semen parametrs in subfertile men: a double-blin, randomized, placebo-controlled study. JBRA Assisted Reproduction, 17(3), 152-157.
  • de Angelis, C., Galdiero, M., Pivonello, C., Garifalos, F., Menafra, D., Cariati, F., . . . Vece, A. (2017). The role of vitamin D in male fertility: a focus on the testis. Reviews in Endocrine and Metabolic Disorders, 18(3), 285-305.
  • Demirci, N. (2014). Erkek Fertilitesi ve Riskli Yaşam Biçimi Davranışları. Florence Nightingale Hemşirelik Dergisi, 22(1), 39-45.
  • Erdemir, F. (2013). Relationship Between Obesity and Male Infertility. J Clin Anal Med, 4, 76-82.
  • Fang, F., Ni, K., Cai, Y., Shang, J., Zhang, X., & Xiong, C. (2017). Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Complementary therapies in clinical practice, 26, 53-60.
  • Gaskins, A. J., & Chavarro, J. E. (2017). Diet and fertility: a review. American journal of obstetrics and gynecology.
  • Heyden, E., & Wimalawansa, S. (2017). Vitamin D: Effects on Human Reproduction, Pregnancy, and Fetal Well-being. The Journal of steroid biochemistry and molecular biology.
  • Imhof, M., Lackner, J., Lipovac, M., Chedraui, P., & Riedl, C. (2012). Improvement of sperm quality after micronutrient supplementation. e-SPEN Journal, 7(1), e50-e53.
  • Karakuş, S., & Doğum, A. (2014). İnfertil Türk kadınlarında seksüel disfonksiyon: Sıklığı ve risk faktörleri. European Journal of Obstetric & Gynecology and Reproductive Biology, 182, 128-131.
  • Koçyiğit, O. T. (2012). İnfertilite ve sosyo-kültürel etkileri. İnsanbilim Dergisi, 1(1), 27-37.
  • Mascarenhas, M. N., Flaxman, S. R., Boerma, T., Vanderpoel, S., & Stevens, G. A. (2012). National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med, 9(12), e1001356.
  • Melodie, V. B., & Christine, W. (2018). Fertility and infertility: Definition and epidemiology. Clinical biochemistry.
  • Nadjarzadeh, A., Sadeghi, M., Amirjannati, N., Vafa, M., Motevalian, S., Gohari, M., . . . Shidfar, F. (2011). Coenzyme Q 10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. Journal of endocrinological investigation, 34(8), e224-e228.
  • Omar, M. I., Pal, R. P., Kelly, B. D., Bruins, H. M., Yuan, Y., Diemer, T., . . . Jungwirth, A. (2019). Benefits of Empiric Nutritional and Medical Therapy for Semen Parameters and Pregnancy and Live Birth Rates in Couples with Idiopathic Infertility: A Systematic Review and Meta-analysis. European urology.
  • Polackwich, A. S., & Sabanegh, E. S. (2015). The Role of Over-the-Counter Supplements in Male Infertility Handbook of Fertility (pp. 369-381): Elsevier.
  • Polak, G., Kozioł-Montewka, M., Gogacz, M., Błaszkowska, I., & Kotarski, J. (2001). Total antioxidant status of peritoneal fluid in infertile women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 94(2), 261-263.
  • Ramlau-Hansen, C. H., Thulstrup, A. M., Nohr, E., Bonde, J. P., Sørensen, T., & Olsen, J. (2007). Subfecundity in overweight and obese couples. Human Reproduction, 22(6), 1634-1637.
  • Ross, C., Morriss, A., Khairy, M., Khalaf, Y., Braude, P., Coomarasamy, A., & El-Toukhy, T. (2010). A systematic review of the effect of oral antioxidants on male infertility. Reproductive biomedicine online, 20(6), 711-723.
  • Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B. (2008). Oxidative stress and antioxidants: exposure and impact on female fertility. Human reproduction update, 14(4), 345-357.
  • Safarinejad, M. R. (2009). Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. The Journal of urology, 182(1), 237-248.
  • Safarinejad, M. R., & Safarinejad, S. (2009). Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. The Journal of urology, 181(2), 741-751.
  • Safarinejad, M. R., Shafiei, N., & Safarinejad, S. (2011). Relationship between genetic polymorphisms of methylenetetra hydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility. Reproductive Sciences, 18(3), 304-315.
  • Sermondade, N., Faure, C., Fezeu, L., Shayeb, A., Bonde, J. P., Jensen, T. K., . . . Eskandar, M. (2012). BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human reproduction update, 19(3), 221-231.
  • Shahrokhi, S. Z., Ghaffari, F., & Kazerouni, F. (2016). Role of vitamin D in female reproduction. Clinica chimica acta, 455, 33-38.
  • Shapiro, A. J., Darmon, S. K., Barad, D. H., Gleicher, N., & Kushnir, V. A. (2018). Vitamin D levels are not associated with ovarian reserve in a group of infertile women with a high prevalance of diminished ovarian reserve. Fertility and sterility, 110(4), 761-766. e761.
  • Smith, R., Kaune, H., Parodi, D., Madariaga, M., Ríos, R., Morales, I., & Castro, A. (2005). Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress. Human Reproduction, 21(4), 986-993.
  • Türk, S., Mändar, R., Mahlapuu, R., Viitak, A., Punab, M., & Kullisaar, T. (2014). Male infertility: decreased levels of selenium, zinc and antioxidants. Journal of trace elements in medicine and biology, 28(2), 179-185.
  • Vaidya, A., Ahmed, K., Brunckhorst, O., Yap, T., & Shabbir, M. (2018). Nutritional supplements in idiopathic male infertility: A systematic review. European Urology Supplements, 17(2), e222.
  • Voulgaris, N., Papanastasiou, L., Piaditis, G., Angelousi, A., Kaltsas, G., Mastorakos, G., & Kassi, E. (2017). Vitamin D and aspects of female fertility. Hormones, 16(1), 5-21.
  • Zhao, J., Dong, X., Hu, X., Long, Z., Wang, L., Liu, Q., . . . Li, L. (2016). Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis. Scientific reports, 6, 22386.

INFERTILITY and MICRONUTRIENTS

Year 2021, Volume: 7 Issue: 1, 1 - 13, 01.02.2021

Rana Nagihan Akder Nurcan Yabancı Ayhan

Abstract

Infertility is defined as not being able to get pregnant in a year despite the regular unprotected sexual intercourse. Infertility is an important health problem affecting the entire world. Adequate and balanced nutrition plays an important role in the prevention and treatment of infertility. Energy balance, body mass index and macro nutrients have obvious effects on infertility. The purpose of this review is to explain the effects of micronutrients on infertility in light of the foregoing scientific data. Micronutrients with antioxidant properties are (such as vitamin A,vitamin C,vitamin E, zinc and selenium) thought to be effective in infertility by preventing DNA damage and destroying free radicals. Folate, vitamin D and vitamin B12 have been shown to be effective in the prevention and treatment of infertility due to the effects of genitourinary system. Further studies are needed to clarify the relationship between micronutrients and infertility and to evaluate the use doses and health benefits of supplements.

Keywords

infertility micronutrients antioxidants

References

  • Akalın, H., & Eryılmaz, G. (2017). Beslenmenin Üreme Sağlığına Etkisi. Turkiye Klinikleri Journal of Obstetric-Women's Health and Diseases Nursing-Special Topics, 3(3), 185-192.
  • Avşar, A. F. Y., Taş, E. E., & Akçay, G. Y. (2013). B-12 vitamini ve infertilite. Ankara Medical Journal, 13(2).
  • Balercia, G., Buldreghini, E., Vignini, A., Tiano, L., Paggi, F., Amoroso, S., . . . Littarru, G. (2009). Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertility and sterility, 91(5), 1785-1792.
  • Bayer, S. R., & Alper, M. M. (2007). Boston IVF Handbook of Infertility: A Practical Guide for Practitioners Who Care for Infertile Couples: CRC Press.
  • Berridge, M. J. (2017). Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). American Journal of Physiology-Cell Physiology, 314(2), C135-C151.
  • Buhling, K. J., Schumacher, A., zu Eulenburg, C., & Laakmann, E. (2019). Influence of oral vitamin and mineral supplementation on male infertility: a meta-analysis and systematic review. Reproductive biomedicine online.
  • Cecchino, G. N., Seli, E., da Motta, E. L. A., & Velasco, J. A. G. (2018). The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights. Reproductive biomedicine online.
  • Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A., & Willett, W. C. (2008). Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility. Fertility and sterility, 89(3), 668-676.
  • Chen, W., Jiao, X., Zhang, J., Wang, L., & Yu, X. (2018). Vitamin D deficiency and high serum IL-6 concentration as risk factors for tubal factor infertility in Chinese women. Nutrition, 49, 24-31. doi:10.1016/j.nut.2017.11.016
  • Çağıran-Yılmaz, F., & Yardımcı, H. (2015). Beden Kütle İndeksinin İnfertilite Üzerine Etkisi. Hacettepe University Faculty of Health Sciences Journal, 1, 1-6.
  • Çayan, S., Özdemir, U. D. A., Orhan, İ., Altay, B., & Kadıoğlu, A. (2015). Oksidatif stresin fertilitiye etkisi ve infertil erkeklerde anti-oksidan tedavinin yeri. Androloji Bülteni, 17, 118-124.
  • da Silva, T. M., Maia, M. C. S., Arruda, J. T., Approbato, F. C., Mendonça, C. R., & Approbato, M. S. (2013). Folic acid does not improve semen parametrs in subfertile men: a double-blin, randomized, placebo-controlled study. JBRA Assisted Reproduction, 17(3), 152-157.
  • de Angelis, C., Galdiero, M., Pivonello, C., Garifalos, F., Menafra, D., Cariati, F., . . . Vece, A. (2017). The role of vitamin D in male fertility: a focus on the testis. Reviews in Endocrine and Metabolic Disorders, 18(3), 285-305.
  • Demirci, N. (2014). Erkek Fertilitesi ve Riskli Yaşam Biçimi Davranışları. Florence Nightingale Hemşirelik Dergisi, 22(1), 39-45.
  • Erdemir, F. (2013). Relationship Between Obesity and Male Infertility. J Clin Anal Med, 4, 76-82.
  • Fang, F., Ni, K., Cai, Y., Shang, J., Zhang, X., & Xiong, C. (2017). Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Complementary therapies in clinical practice, 26, 53-60.
  • Gaskins, A. J., & Chavarro, J. E. (2017). Diet and fertility: a review. American journal of obstetrics and gynecology.
  • Heyden, E., & Wimalawansa, S. (2017). Vitamin D: Effects on Human Reproduction, Pregnancy, and Fetal Well-being. The Journal of steroid biochemistry and molecular biology.
  • Imhof, M., Lackner, J., Lipovac, M., Chedraui, P., & Riedl, C. (2012). Improvement of sperm quality after micronutrient supplementation. e-SPEN Journal, 7(1), e50-e53.
  • Karakuş, S., & Doğum, A. (2014). İnfertil Türk kadınlarında seksüel disfonksiyon: Sıklığı ve risk faktörleri. European Journal of Obstetric & Gynecology and Reproductive Biology, 182, 128-131.
  • Koçyiğit, O. T. (2012). İnfertilite ve sosyo-kültürel etkileri. İnsanbilim Dergisi, 1(1), 27-37.
  • Mascarenhas, M. N., Flaxman, S. R., Boerma, T., Vanderpoel, S., & Stevens, G. A. (2012). National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med, 9(12), e1001356.
  • Melodie, V. B., & Christine, W. (2018). Fertility and infertility: Definition and epidemiology. Clinical biochemistry.
  • Nadjarzadeh, A., Sadeghi, M., Amirjannati, N., Vafa, M., Motevalian, S., Gohari, M., . . . Shidfar, F. (2011). Coenzyme Q 10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. Journal of endocrinological investigation, 34(8), e224-e228.
  • Omar, M. I., Pal, R. P., Kelly, B. D., Bruins, H. M., Yuan, Y., Diemer, T., . . . Jungwirth, A. (2019). Benefits of Empiric Nutritional and Medical Therapy for Semen Parameters and Pregnancy and Live Birth Rates in Couples with Idiopathic Infertility: A Systematic Review and Meta-analysis. European urology.
  • Polackwich, A. S., & Sabanegh, E. S. (2015). The Role of Over-the-Counter Supplements in Male Infertility Handbook of Fertility (pp. 369-381): Elsevier.
  • Polak, G., Kozioł-Montewka, M., Gogacz, M., Błaszkowska, I., & Kotarski, J. (2001). Total antioxidant status of peritoneal fluid in infertile women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 94(2), 261-263.
  • Ramlau-Hansen, C. H., Thulstrup, A. M., Nohr, E., Bonde, J. P., Sørensen, T., & Olsen, J. (2007). Subfecundity in overweight and obese couples. Human Reproduction, 22(6), 1634-1637.
  • Ross, C., Morriss, A., Khairy, M., Khalaf, Y., Braude, P., Coomarasamy, A., & El-Toukhy, T. (2010). A systematic review of the effect of oral antioxidants on male infertility. Reproductive biomedicine online, 20(6), 711-723.
  • Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B. (2008). Oxidative stress and antioxidants: exposure and impact on female fertility. Human reproduction update, 14(4), 345-357.
  • Safarinejad, M. R. (2009). Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. The Journal of urology, 182(1), 237-248.
  • Safarinejad, M. R., & Safarinejad, S. (2009). Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. The Journal of urology, 181(2), 741-751.
  • Safarinejad, M. R., Shafiei, N., & Safarinejad, S. (2011). Relationship between genetic polymorphisms of methylenetetra hydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility. Reproductive Sciences, 18(3), 304-315.
  • Sermondade, N., Faure, C., Fezeu, L., Shayeb, A., Bonde, J. P., Jensen, T. K., . . . Eskandar, M. (2012). BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human reproduction update, 19(3), 221-231.
  • Shahrokhi, S. Z., Ghaffari, F., & Kazerouni, F. (2016). Role of vitamin D in female reproduction. Clinica chimica acta, 455, 33-38.
  • Shapiro, A. J., Darmon, S. K., Barad, D. H., Gleicher, N., & Kushnir, V. A. (2018). Vitamin D levels are not associated with ovarian reserve in a group of infertile women with a high prevalance of diminished ovarian reserve. Fertility and sterility, 110(4), 761-766. e761.
  • Smith, R., Kaune, H., Parodi, D., Madariaga, M., Ríos, R., Morales, I., & Castro, A. (2005). Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress. Human Reproduction, 21(4), 986-993.
  • Türk, S., Mändar, R., Mahlapuu, R., Viitak, A., Punab, M., & Kullisaar, T. (2014). Male infertility: decreased levels of selenium, zinc and antioxidants. Journal of trace elements in medicine and biology, 28(2), 179-185.
  • Vaidya, A., Ahmed, K., Brunckhorst, O., Yap, T., & Shabbir, M. (2018). Nutritional supplements in idiopathic male infertility: A systematic review. European Urology Supplements, 17(2), e222.
  • Voulgaris, N., Papanastasiou, L., Piaditis, G., Angelousi, A., Kaltsas, G., Mastorakos, G., & Kassi, E. (2017). Vitamin D and aspects of female fertility. Hormones, 16(1), 5-21.
  • Zhao, J., Dong, X., Hu, X., Long, Z., Wang, L., Liu, Q., . . . Li, L. (2016). Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis. Scientific reports, 6, 22386.
There are 41 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Articles
Authors

Rana Nagihan Akder 0000-0002-2700-5050

Nurcan Yabancı Ayhan 0000-0003-1233-246X

Publication Date February 1, 2021
Submission Date October 19, 2020
Acceptance Date November 25, 2020
Published in Issue Year 2021 Volume: 7 Issue: 1

Cite

APA Akder, R. N., & Yabancı Ayhan, N. (2021). İnfertilite ve Mikro Besin Ögeleri. Aydın Sağlık Dergisi, 7(1), 1-13.
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