BibTex RIS Cite

FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS

Year 2016, Volume: 3 Issue: 1, 40 - 6, 15.01.2016

Serkan Demir Rifat Togrol Ali Sonkaya Mustafa Kendirli Semih Alay Tugba Celik Sakir Delil Mehmet Ozdag

Abstract

Objective:In this study the factors that trigger the seizures in epileptic patients over the age of 50 was investigated and the frequency of seizures was analyzed regarding different age, gender, type of seizure and etiological groups.

Method:  For this purpose, 387 patients were included in the study who were admitted to neurology outpatient clinic with the diagnosis of epilepsy. The patients are divided into groups based on those characteristics: male / female, generalized seizure / partial seizure, age between 50 and 65 / age over 65, they were evaluated in terms of seizure triggers.

Result: The most common precipitating factor in all groups were found as stress (37%), sleeplessness (27%) and forgetting to take the medication (20%). 31% of the patients were on Carbamazepine, 21% were on Levetiracetam and 19% were on Valproic Asid. The most common etiological causes were identified as idiopathic (39%), poststroke(24%) and dementia (15%). Regarding the triggering factor, some statistically significant differences were found between the following groups and control groups; the group with patients between the age 50 and 65: stress, fatigue, waking and sleeping; the group with female patients: sleeplessness; the group with the generalized seizures: alcohol and sleep. 

Conclusion:  In conclusion 68% of our patients complained about at least one seizure precipitant and the most common precipitants were stress, sleeplessness and missing dose of medication. In this study, age between 50 and 65 group is more affected by triggers.

Keywords: Epilepsy, Seizure precipitants, Stress, Sleeplessness

Keywords

Epilepsy Seizure precipitants Stress Sleeplessness

References

  • Shovon S.D. Epidemiology, classification, natural history and genetics of epilepsy. Lancet 1990;336: 93- 96
  • Banerjee PN, Filippi D, Hauser WA. The descriptive epidemiology of epilepsy. Epilepsy Research 2009; 85:31-45
  • Hauser WA. Seizure disorders: the chances with age. Epilepsia 1992;33(suppl4):6-7
  • Spector S, Cull C, Goldstein LH. Seizure precipitants and perceived self-control of seizures in adults with poorly-controlled epilepsy. Epilepsy Research 2000; 38; 207- 216
  • Courte DL, Breteler MM, Meinardi H, Hauser A, Hoffman A. Prevelance of epilepsy in the elderly: the Rotterdam study: Epilepsia 1996;37:141-147
  • Stephen L, Brodie M. Epilepsy in elderly people. The Lancet 2000;355:1441-1446
  • DeToledo JC. Changing presentation of seizeures with aging: Clinical and etiological factors. Gerontology 1999;45:329-335
  • Cloyd J, Hauser W, Towne A, Ramsay R, Mattson R, Gliam F, Walczak T. Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Research 2006;68:39-48
  • Tascılar NF, Bozdemır H, Aslan K, Sarıca Y, Seydaolu G. Yaşlı epilepsi hastalarında elektroensefalografinin yeri. Epilepsi 2006;12(1):32-41
  • Mendez MF, Catanzaro P, Doss RC. Seizures in Alzheimer's disease: Clinicopathologic study. J Geriatr Psychiatry Neurol 1994;7:230-233
  • Wilmore LJ. Management of epilepsy in the elderly. Epilepsia 1996;37(6):23-33
  • Stephen L, Brodie M. Epilepsy in elderly people. The Lancet 2000;355:1441-1446
  • Berkovic SF: Treatment with anti- epileptic drugs. Aust Fam Physician. 2005; 34: 1017-1020.
  • Dorothee GA. Provaked and reflex seizures: Suprising and common? Epilepsia 2012; 53(4):105-112
  • Pinikahana J, Dono J. Age and gender differences in initial symptoms and precipitant factors of epileptic seizures: An Australian study. Epilepsy and Behaviour 2009; 16: 231-239
  • Lunardi MDS, Sukys-Claudino L, Guarnieri R, Walz R, Lin K. Seizure precipitants and inhibiting factors in mesial temporal lobe epilepsy. Journal of the neurological sciences 2011;308:21-24
  • Spector S, Cull C,Goldstein L. Seizure precipitants and perceived self-control of seizures in adults with poorly-controlled epilepsy. Epilepsy Research 2000;38:207-216
  • Fang PC, Chen YC, Lee IC. Seizure precipitants in children with intractable epilepsy. Brain & Development 2008; 30 527–532
  • Oto R, Apak İ, Arslan S, Yavavlı A, Altındağ A, Karaca EE. Epilepsinin psikososyal etkileri. Klinik Psikyatri Dergisi 2004; 7:210-214
  • Baker GA, Jacoby A, Buck D. Quality of life people with epilepsy. Epilepsia 1997; 38: 353-362
  • Nancy RT, Gay D. Stress as a risk factor for seizure among adults with epilepsy. Epilepsia 2008; 43: 456-468
  • Chadwick D. Epilepsy. J Neurol Neurosurg Psychiatry. 1994;57(3):264-77
  • Swinkels WA, Kuyk J, van Dyck R, Spinhoven P. Psychiatric comorbidity in epilepsy. Epilepsy Behav. 2005;7:37-50.
  • Sachdev P. Schizophrenia-like psychosis and epilepsy: the status of the association. Am J Psychiatry. 1998;155:325-336.
  • Kristensen O, Sindrup EH. Psychomotor epilepsy and psychosis. I. Physical aspects. Acta Neurol Scand. 1978;57:361-369
  • Slater E, Beard AW, Glithero E. The schizophrenialike psychoses of epilepsy. Br J Psychiatry. 1963;109:95-150
  • Suurmeijer TP, Reuvekamp MF, Aldenkamp BP. Social functioning, psychological functioning, and quality of, life in epilepsy. Epilepsia 2001;42(9):1160-1168
  • Jalava M, Sillanpaa M. Concurrent illness in adult with childhood-onset epilepsy: a population-based 35 year follow up study. Epilepsia 1996;1155-1163
  • Nancy RT, Gay D. Stress as a risk factor for seizure among adults with epilepsy. Epilepsia 2008; 43: 456-468Silber MH. Sleep Disorders. Neurol Clin 2001;1,173-186
  • Baker GA, Jacoby A, Buck D. Quality of life people with epilepsy. Epilepsia 1997; 38: 353-362
  • Nakken KO, Solaas MH, Kjeldsen MJ. Which seizures precitating factors do patients with epilepsy most frequently report? Epilepsy Behav 2005;6:185-189
  • Frucht MM, Quigg M, Schwazer C. Distrubituion of seizure precipitants among epilepsy syndromes. Epilepsia 2000;41:1534-1539
  • Sperling MR, Schilling CA, Glosser D, Tracy JI. Self-perception of seizure precipitants and their relation the anxiety level, depression, and health locus of control in epilepsy. Seizure 2008;17:302-307
  • Hart YM, Shorvon SD. The Nature Of Epilepsy İn Teh General Population: I: characteristics of of patients receiving medication for epilpsy. Epilepsy Res 1995; 21:43- 49
  • Cull CA, Fowler M, Brown SW. Perceived self control of seizures in young people with epilpsy. Seizure 1996;5:131-138
  • Friedman RA, Cacheaux LP, Ivens S, Kaufer D. Elucidating the complex interactions between stres and epileptogenic pathways. Cardiovasc Psychiatry Neurol. 2011; 10; 1-8
  • Salgado PC, Souza EA. Quality of life in epilepsy and perception of seizure control. Arg Neuropsiquiatr 2001; 59: 537-40.
  • Birbeck GL, Ron D, Hays RD et al. Seizure reduction and quality of life improvements in people with epilepsy. Epilepsia 2002; 43:535-8.
  • Silber MH. Sleep Disorders. Neurol Clin 2001;1,173-186
  • www.sleepfoundatiom.org Women and Sleep

Factors triggering epileptic seizures in patients over 50 years

Year 2016, Volume: 3 Issue: 1, 40 - 6, 15.01.2016

Serkan Demir Rifat Togrol Ali Sonkaya Mustafa Kendirli Semih Alay Tugba Celik Sakir Delil Mehmet Ozdag

Abstract

References

  • Shovon S.D. Epidemiology, classification, natural history and genetics of epilepsy. Lancet 1990;336: 93- 96
  • Banerjee PN, Filippi D, Hauser WA. The descriptive epidemiology of epilepsy. Epilepsy Research 2009; 85:31-45
  • Hauser WA. Seizure disorders: the chances with age. Epilepsia 1992;33(suppl4):6-7
  • Spector S, Cull C, Goldstein LH. Seizure precipitants and perceived self-control of seizures in adults with poorly-controlled epilepsy. Epilepsy Research 2000; 38; 207- 216
  • Courte DL, Breteler MM, Meinardi H, Hauser A, Hoffman A. Prevelance of epilepsy in the elderly: the Rotterdam study: Epilepsia 1996;37:141-147
  • Stephen L, Brodie M. Epilepsy in elderly people. The Lancet 2000;355:1441-1446
  • DeToledo JC. Changing presentation of seizeures with aging: Clinical and etiological factors. Gerontology 1999;45:329-335
  • Cloyd J, Hauser W, Towne A, Ramsay R, Mattson R, Gliam F, Walczak T. Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Research 2006;68:39-48
  • Tascılar NF, Bozdemır H, Aslan K, Sarıca Y, Seydaolu G. Yaşlı epilepsi hastalarında elektroensefalografinin yeri. Epilepsi 2006;12(1):32-41
  • Mendez MF, Catanzaro P, Doss RC. Seizures in Alzheimer's disease: Clinicopathologic study. J Geriatr Psychiatry Neurol 1994;7:230-233
  • Wilmore LJ. Management of epilepsy in the elderly. Epilepsia 1996;37(6):23-33
  • Stephen L, Brodie M. Epilepsy in elderly people. The Lancet 2000;355:1441-1446
  • Berkovic SF: Treatment with anti- epileptic drugs. Aust Fam Physician. 2005; 34: 1017-1020.
  • Dorothee GA. Provaked and reflex seizures: Suprising and common? Epilepsia 2012; 53(4):105-112
  • Pinikahana J, Dono J. Age and gender differences in initial symptoms and precipitant factors of epileptic seizures: An Australian study. Epilepsy and Behaviour 2009; 16: 231-239
  • Lunardi MDS, Sukys-Claudino L, Guarnieri R, Walz R, Lin K. Seizure precipitants and inhibiting factors in mesial temporal lobe epilepsy. Journal of the neurological sciences 2011;308:21-24
  • Spector S, Cull C,Goldstein L. Seizure precipitants and perceived self-control of seizures in adults with poorly-controlled epilepsy. Epilepsy Research 2000;38:207-216
  • Fang PC, Chen YC, Lee IC. Seizure precipitants in children with intractable epilepsy. Brain & Development 2008; 30 527–532
  • Oto R, Apak İ, Arslan S, Yavavlı A, Altındağ A, Karaca EE. Epilepsinin psikososyal etkileri. Klinik Psikyatri Dergisi 2004; 7:210-214
  • Baker GA, Jacoby A, Buck D. Quality of life people with epilepsy. Epilepsia 1997; 38: 353-362
  • Nancy RT, Gay D. Stress as a risk factor for seizure among adults with epilepsy. Epilepsia 2008; 43: 456-468
  • Chadwick D. Epilepsy. J Neurol Neurosurg Psychiatry. 1994;57(3):264-77
  • Swinkels WA, Kuyk J, van Dyck R, Spinhoven P. Psychiatric comorbidity in epilepsy. Epilepsy Behav. 2005;7:37-50.
  • Sachdev P. Schizophrenia-like psychosis and epilepsy: the status of the association. Am J Psychiatry. 1998;155:325-336.
  • Kristensen O, Sindrup EH. Psychomotor epilepsy and psychosis. I. Physical aspects. Acta Neurol Scand. 1978;57:361-369
  • Slater E, Beard AW, Glithero E. The schizophrenialike psychoses of epilepsy. Br J Psychiatry. 1963;109:95-150
  • Suurmeijer TP, Reuvekamp MF, Aldenkamp BP. Social functioning, psychological functioning, and quality of, life in epilepsy. Epilepsia 2001;42(9):1160-1168
  • Jalava M, Sillanpaa M. Concurrent illness in adult with childhood-onset epilepsy: a population-based 35 year follow up study. Epilepsia 1996;1155-1163
  • Nancy RT, Gay D. Stress as a risk factor for seizure among adults with epilepsy. Epilepsia 2008; 43: 456-468Silber MH. Sleep Disorders. Neurol Clin 2001;1,173-186
  • Baker GA, Jacoby A, Buck D. Quality of life people with epilepsy. Epilepsia 1997; 38: 353-362
  • Nakken KO, Solaas MH, Kjeldsen MJ. Which seizures precitating factors do patients with epilepsy most frequently report? Epilepsy Behav 2005;6:185-189
  • Frucht MM, Quigg M, Schwazer C. Distrubituion of seizure precipitants among epilepsy syndromes. Epilepsia 2000;41:1534-1539
  • Sperling MR, Schilling CA, Glosser D, Tracy JI. Self-perception of seizure precipitants and their relation the anxiety level, depression, and health locus of control in epilepsy. Seizure 2008;17:302-307
  • Hart YM, Shorvon SD. The Nature Of Epilepsy İn Teh General Population: I: characteristics of of patients receiving medication for epilpsy. Epilepsy Res 1995; 21:43- 49
  • Cull CA, Fowler M, Brown SW. Perceived self control of seizures in young people with epilpsy. Seizure 1996;5:131-138
  • Friedman RA, Cacheaux LP, Ivens S, Kaufer D. Elucidating the complex interactions between stres and epileptogenic pathways. Cardiovasc Psychiatry Neurol. 2011; 10; 1-8
  • Salgado PC, Souza EA. Quality of life in epilepsy and perception of seizure control. Arg Neuropsiquiatr 2001; 59: 537-40.
  • Birbeck GL, Ron D, Hays RD et al. Seizure reduction and quality of life improvements in people with epilepsy. Epilepsia 2002; 43:535-8.
  • Silber MH. Sleep Disorders. Neurol Clin 2001;1,173-186
  • www.sleepfoundatiom.org Women and Sleep
There are 40 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Serkan Demir

Rifat Togrol This is me

Ali Sonkaya

Mustafa Kendirli This is me

Semih Alay This is me

Tugba Celik This is me

Sakir Delil This is me

Mehmet Ozdag This is me

Publication Date January 15, 2016
Published in Issue Year 2016 Volume: 3 Issue: 1

Cite

APA Demir, S., Togrol, R., Sonkaya, A., Kendirli, M., et al. (2016). FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS. Medical Science and Discovery, 3(1), 40-6. https://doi.org/10.17546/msd.80815
AMA Demir S, Togrol R, Sonkaya A, Kendirli M, Alay S, Celik T, Delil S, Ozdag M. FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS. Med Sci Discov. January 2016;3(1):40-6. doi:10.17546/msd.80815
Chicago Demir, Serkan, Rifat Togrol, Ali Sonkaya, Mustafa Kendirli, Semih Alay, Tugba Celik, Sakir Delil, and Mehmet Ozdag. “FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS”. Medical Science and Discovery 3, no. 1 (January 2016): 40-6. https://doi.org/10.17546/msd.80815.
EndNote Demir S, Togrol R, Sonkaya A, Kendirli M, Alay S, Celik T, Delil S, Ozdag M (January 1, 2016) FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS. Medical Science and Discovery 3 1 40–6.
IEEE S. Demir, “FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS”, Med Sci Discov, vol. 3, no. 1, pp. 40–6, 2016, doi: 10.17546/msd.80815.
ISNAD Demir, Serkan et al. “FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS”. Medical Science and Discovery 3/1 (January 2016), 40-6. https://doi.org/10.17546/msd.80815.
JAMA Demir S, Togrol R, Sonkaya A, Kendirli M, Alay S, Celik T, Delil S, Ozdag M. FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS. Med Sci Discov. 2016;3:40–6.
MLA Demir, Serkan et al. “FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS”. Medical Science and Discovery, vol. 3, no. 1, 2016, pp. 40-6, doi:10.17546/msd.80815.
Vancouver Demir S, Togrol R, Sonkaya A, Kendirli M, Alay S, Celik T, Delil S, Ozdag M. FACTORS TRIGGERING EPILEPTIC SEIZURES IN PATIENTS OVER 50 YEARS. Med Sci Discov. 2016;3(1):40-6.
 Download Cover Image