Araştırma Makalesi
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Yıl 2022, Cilt: 6 Sayı: 3, 836 - 841, 29.09.2022
https://doi.org/10.30621/jbachs.1004347

Öz

Kaynakça

  • J.A. McCaul, A. Aslaam, R. J. Spooner, I.Louden, T. Cavanagh, A. D. Purushotham. Aetiology of seroma formation in patients undergoing surgery for breast cancer. The Breast 2000;9:144-148. PMID: 14731838
  • Ernest A. Gonzalez, MD, Edward C. Saltzstein, MD, Carola S. Riedner, MD, Brian K. Nelson, MD. Seroma Formation Following Breast Cancer Surgery. The Breast Journal 2003;9(5):385-388. PMID: 12968958
  • Esmat Hashemi, Ahmad Kaviani, Masoume Najafi, Mandana Ebrahimi, Homeira Hooshmand, Ali Montazeri. Seroma formation after surgery for breast cancer. World J Surg Oncol. 2004;2:44. PMID: 15588301
  • Katsumasa Kuroi, Kojiro shimozuma, Tetsuya Taguchi, Hirohisa Imai, Hiroyasu Yamashiro, Shozo Ohsumi, Shinya Saito. Pathophysiology of Seroma in Breast Cancer. Breast Cancer 2005; 12(4):288-293. PMID: 16286909
  • C. J. Pogson, A. Adwani and S. R. Ebbs. Seroma following breast cancer surgery. European Journal of Surgical Oncology 2003;29:711-717. PMID: 14602488
  • Turner EJ1, Benson JR, Winters ZE. Techniques in the prevention and management of seromas after breast surgery. Future Oncol. 2014 May;10(6):1049-63. PMID: 24941989
  • Chung TL1, Holton LH 3rd, Goldberg NH, Silverman RP. Seroma prevention using Mytilus edulis protein in a rat mastectomy model. Breast J. 2006 Sep-Oct;12(5):442-5. PMID: 16958963
  • E.Tekin, M. A. Kocdor, S. Saydam, S. Bora, O. Harmancioğlu. Seroma Prevention by Using Corynebacterium parvum in a Rat Mastektomi Model. Eur Surg Res 2001;33:245- 248. PMID: 11490129
  • Katsumasa Kuroi, Kojiro Shimozuma, Tetsuya Taguchi, Hirohisa Imai, Hiroyasu Yamashiro, Shozo Ohsumi, Shinya Saito. Evidence –Based Risk Factors for seroma formation in Breast Surgery. Jpn J Clin Oncol 2006;36(4):197-206. PMID: 16684859
  • William E. Stehbens. Postmastectomy serous drainage and seroma: probable pathogenesis and prevention. ANZ J. Surg. 2003;73:877-880. PMID: 14616557
  • Oertli D1, Laffer U, Haberthuer F, Kreuter U, Harder F. Perioperative and postoperative tranexamic acid reduces the local wound complication rate after surgery for breast cancer. Br. J. Surg. 1994; 81: 856–9. PMID: 8044602
  • Vaxman F1, Kolbe A, Stricher F, Zund D, Volkmar P, Gros D, Grenier JF. Does fibrin glue improve drainage after axillary lymph node dissection? Prospective and randomized clinical study in humans. Eur Surg Res 1995; 27: 346-352. PMID: 7589007
  • Petrek JA1, Peters MM, Nori S, Knauer C, Kinne DW, Rogatko A. Axillary lymphadenectomy. A prospective, randomized trial of 13 factors influencing drainage, including early or delayed arm mobilization. Arch. Surg. 1990; 125: 378–82. PMID: 2407228
  • Gonzalez EA1, Saltzstein EC, Riedner CS, Nelson BK. Seroma formation following breast cancer surgery. Breast J. 2003; 9: 385–8. PMID: 12968958
  • Hashemi E1, Kaviani A, Najafi M, Ebrahimi M, Hooshmand H, Montazeri A. Seroma formation after surgery for breast cancer. World J. Surg. Oncol. 2004; 2: 44. PMID: 15588301
  • Rice DC1, Morris SM, Sarr MG, Farnell MB, van Heerden JA, Grant CS, Rowland CM, Ilstrup DM, Donohue JH. İntraoperative topical tetracycline sclerotherapy following mastectomy, a prospective randomized trial. J Surg Oncol 2000;73:224-227. PMID: 10797336
  • O'Hea BJ, Ho MN, Petrek JA. External compression dressing versus standard dressing after axillary lymphadenectomy. Am J Surg. 1999 Jun;177(6):450-3. PMID: 10414691
  • Rajkumar Kottayasamy Seenivasagam, Vikas Gupta, Gurpreet Singh. Preventıon of seroma formatıon after axıllary dıssectıon--a comparatıve randomızed clınıcal trıal of three methods. Breast J 2013 Sep-Oct;19(5):478-84. Epub 2013 Jul 19. PMID: 23865902
  • Parikh HK1, Badwe RA, Ash CM, Hamed H, Freitas R Jr, Chaudary MA, Fentiman IS. Early drain removal following modified radical mastectomy: a randomised trial. J Surg Oncol 1992; 51: 266-269. PMID: 1434659
  • Purushotham AD1, McLatchie E, Young D, George WD, Stallard S, Doughty J, Brown DC, Farish C, Walker A, Millar K, Murray G. Randomised clinical trial of no wound drains and early discharge in the treatment of women with breast cancer. Br J Surg 2002; 89: 286-292. PMID: 11872051
  • Coveney EC1, O'Dwyer PJ, Geraghty JG, O'Higgins NJ. Effect of closing dead space on seroma formation after mastectomy: a prospective randomised cilnical trial. Eur J Surg Oncol 1993; 19; 143-146. PMID: 8491318
  • Watt-Boolsen S1, Nielsen VB, Jensen J, Bak S. Postmastectomy seroma. A study of the nature and origin of seroma after mastectomy. Dan. Med. Bull. 1989; 36: 487–9. PMID: 2509147
  • Wang JY1, Goodman NC, Amiss LR Jr, Nguyen DH, Rodeheaver GT, Moore MM, Morgan RF, Abbott RD, Spotnitz WD. Seroma prevention in a rat mastectomy model: use of a light-activated fibrin sealant. Ann Plast Surg. 1996,37:400-405. PMID: 8905048
  • Styblo TM1, Wood WC. Adjuvant chemotherapy in the node-negative breast cancer patient. The Surg Clin Nor Am, 1996:327-343. PMID: 8610267
  • Budd DC, Cochran RC, Sturtz DL, Fouty WJ Jr.. Surgical morbidity after mastectomy operations. Am. J. Surg. 1978; 135: 218–20. PMID: 626296
  • Gerstein AD1, Phillips TJ, Rogers GS, Gilchrest BA. Wound healing and aging. Dermatol Clin. 1993 Oct;11(4):749-57. PMID: 8222358
  • Barbul A, Purtill WA Nutrition in wound healing. Clin Dermatol. 1994; 12:133. PMID: 8180936

Importance of Nutrition in the development of Seroma after Breast Surgery

Yıl 2022, Cilt: 6 Sayı: 3, 836 - 841, 29.09.2022
https://doi.org/10.30621/jbachs.1004347

Öz

Amaç: Meme cerrahisi sonrası seroma gelişiminde nütrisyonun önemini araştırmak. Seroma mastektomi sonrası görülen en sık komplikasyon olup, görülme sıklığı %10- 50 arasında değişmektedir. Seroma cilt nekrozu, enfeksiyon, yara iyileşmesini gecikmesi ve bunun sonucu olarak ek tedavilerin gecikmesine neden olabileceği için ciddiye alınması gereken bir komplikasyondur.
Metod: Bu deneysel çalışmada 10’arlı gruplara ayrılan toplan 40 rat kullanıldı. Preoperatif 7 gün boyunca 1.gruba (kontrol) normal rat gıdası, 2. gruba kontrol grubunun %70’i kadar normal rat gıdası (malnütrisyon), 3. ve 4. gruba proteinden zengin diyet (Glutamin-Arjinin-Metil Bütirat) (10gr protein /kg/gün) verildi ve gruplara 7. gün tek taraflı (sağ) pektoral majör kas eksizyonu ve aksiler diseksiyon uygulandı. Postoperatif 10 gün boyunca 1. gruba normal rat gıdası, 2. gruba kontrol grubunun %70’ i kadar normal rat gıdası, 3. gruba normal rat gıdası ve 4. gruba proteinden zengin diyet verildi. Postoperatif 10. günde ratlardan seroma örneği alınarak sakrifiye edildi.
Bulgular: Kontrol grubunun seroma miktarı 1,5 ml (1ml-2,5ml), malnütrüsyon grubunun seroma miktarı 1,5ml (1ml-2,75ml), preoperatif proteinden zengin diyetle beslenen 3.grubun seroma miktarı 1ml (0,5ml-1ml), preoperatif ve postoperatif proteinden zengin diyetle beslenen 4.grubun seroma miktarı 0,75ml (0,5ml-1ml) olarak bulundu. Seroma miktarları ortanca olarak verildi. Bu değerlere göre proteinden zengin diyetle beslenen grupların seroma miktarları anlamlı olarak düşük bulundu. (p=0,001 )
Sonuç: Çalışmamızda elde edilen veriler doğrultusunda deneysel mastektomi ve aksiller diseksiyon (AD) modelinde preoperatif ve postoperatif dönemde proteinden yüksek diyetle beslenmenin seroma oluşumunu azalttığı görülmüştür. Benzer şekilde klinik çalışmaların planlanması gerektiği kanaatindeyiz.

Kaynakça

  • J.A. McCaul, A. Aslaam, R. J. Spooner, I.Louden, T. Cavanagh, A. D. Purushotham. Aetiology of seroma formation in patients undergoing surgery for breast cancer. The Breast 2000;9:144-148. PMID: 14731838
  • Ernest A. Gonzalez, MD, Edward C. Saltzstein, MD, Carola S. Riedner, MD, Brian K. Nelson, MD. Seroma Formation Following Breast Cancer Surgery. The Breast Journal 2003;9(5):385-388. PMID: 12968958
  • Esmat Hashemi, Ahmad Kaviani, Masoume Najafi, Mandana Ebrahimi, Homeira Hooshmand, Ali Montazeri. Seroma formation after surgery for breast cancer. World J Surg Oncol. 2004;2:44. PMID: 15588301
  • Katsumasa Kuroi, Kojiro shimozuma, Tetsuya Taguchi, Hirohisa Imai, Hiroyasu Yamashiro, Shozo Ohsumi, Shinya Saito. Pathophysiology of Seroma in Breast Cancer. Breast Cancer 2005; 12(4):288-293. PMID: 16286909
  • C. J. Pogson, A. Adwani and S. R. Ebbs. Seroma following breast cancer surgery. European Journal of Surgical Oncology 2003;29:711-717. PMID: 14602488
  • Turner EJ1, Benson JR, Winters ZE. Techniques in the prevention and management of seromas after breast surgery. Future Oncol. 2014 May;10(6):1049-63. PMID: 24941989
  • Chung TL1, Holton LH 3rd, Goldberg NH, Silverman RP. Seroma prevention using Mytilus edulis protein in a rat mastectomy model. Breast J. 2006 Sep-Oct;12(5):442-5. PMID: 16958963
  • E.Tekin, M. A. Kocdor, S. Saydam, S. Bora, O. Harmancioğlu. Seroma Prevention by Using Corynebacterium parvum in a Rat Mastektomi Model. Eur Surg Res 2001;33:245- 248. PMID: 11490129
  • Katsumasa Kuroi, Kojiro Shimozuma, Tetsuya Taguchi, Hirohisa Imai, Hiroyasu Yamashiro, Shozo Ohsumi, Shinya Saito. Evidence –Based Risk Factors for seroma formation in Breast Surgery. Jpn J Clin Oncol 2006;36(4):197-206. PMID: 16684859
  • William E. Stehbens. Postmastectomy serous drainage and seroma: probable pathogenesis and prevention. ANZ J. Surg. 2003;73:877-880. PMID: 14616557
  • Oertli D1, Laffer U, Haberthuer F, Kreuter U, Harder F. Perioperative and postoperative tranexamic acid reduces the local wound complication rate after surgery for breast cancer. Br. J. Surg. 1994; 81: 856–9. PMID: 8044602
  • Vaxman F1, Kolbe A, Stricher F, Zund D, Volkmar P, Gros D, Grenier JF. Does fibrin glue improve drainage after axillary lymph node dissection? Prospective and randomized clinical study in humans. Eur Surg Res 1995; 27: 346-352. PMID: 7589007
  • Petrek JA1, Peters MM, Nori S, Knauer C, Kinne DW, Rogatko A. Axillary lymphadenectomy. A prospective, randomized trial of 13 factors influencing drainage, including early or delayed arm mobilization. Arch. Surg. 1990; 125: 378–82. PMID: 2407228
  • Gonzalez EA1, Saltzstein EC, Riedner CS, Nelson BK. Seroma formation following breast cancer surgery. Breast J. 2003; 9: 385–8. PMID: 12968958
  • Hashemi E1, Kaviani A, Najafi M, Ebrahimi M, Hooshmand H, Montazeri A. Seroma formation after surgery for breast cancer. World J. Surg. Oncol. 2004; 2: 44. PMID: 15588301
  • Rice DC1, Morris SM, Sarr MG, Farnell MB, van Heerden JA, Grant CS, Rowland CM, Ilstrup DM, Donohue JH. İntraoperative topical tetracycline sclerotherapy following mastectomy, a prospective randomized trial. J Surg Oncol 2000;73:224-227. PMID: 10797336
  • O'Hea BJ, Ho MN, Petrek JA. External compression dressing versus standard dressing after axillary lymphadenectomy. Am J Surg. 1999 Jun;177(6):450-3. PMID: 10414691
  • Rajkumar Kottayasamy Seenivasagam, Vikas Gupta, Gurpreet Singh. Preventıon of seroma formatıon after axıllary dıssectıon--a comparatıve randomızed clınıcal trıal of three methods. Breast J 2013 Sep-Oct;19(5):478-84. Epub 2013 Jul 19. PMID: 23865902
  • Parikh HK1, Badwe RA, Ash CM, Hamed H, Freitas R Jr, Chaudary MA, Fentiman IS. Early drain removal following modified radical mastectomy: a randomised trial. J Surg Oncol 1992; 51: 266-269. PMID: 1434659
  • Purushotham AD1, McLatchie E, Young D, George WD, Stallard S, Doughty J, Brown DC, Farish C, Walker A, Millar K, Murray G. Randomised clinical trial of no wound drains and early discharge in the treatment of women with breast cancer. Br J Surg 2002; 89: 286-292. PMID: 11872051
  • Coveney EC1, O'Dwyer PJ, Geraghty JG, O'Higgins NJ. Effect of closing dead space on seroma formation after mastectomy: a prospective randomised cilnical trial. Eur J Surg Oncol 1993; 19; 143-146. PMID: 8491318
  • Watt-Boolsen S1, Nielsen VB, Jensen J, Bak S. Postmastectomy seroma. A study of the nature and origin of seroma after mastectomy. Dan. Med. Bull. 1989; 36: 487–9. PMID: 2509147
  • Wang JY1, Goodman NC, Amiss LR Jr, Nguyen DH, Rodeheaver GT, Moore MM, Morgan RF, Abbott RD, Spotnitz WD. Seroma prevention in a rat mastectomy model: use of a light-activated fibrin sealant. Ann Plast Surg. 1996,37:400-405. PMID: 8905048
  • Styblo TM1, Wood WC. Adjuvant chemotherapy in the node-negative breast cancer patient. The Surg Clin Nor Am, 1996:327-343. PMID: 8610267
  • Budd DC, Cochran RC, Sturtz DL, Fouty WJ Jr.. Surgical morbidity after mastectomy operations. Am. J. Surg. 1978; 135: 218–20. PMID: 626296
  • Gerstein AD1, Phillips TJ, Rogers GS, Gilchrest BA. Wound healing and aging. Dermatol Clin. 1993 Oct;11(4):749-57. PMID: 8222358
  • Barbul A, Purtill WA Nutrition in wound healing. Clin Dermatol. 1994; 12:133. PMID: 8180936
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Research Article
Yazarlar

Berke Manoğlu 0000-0003-4755-2200

Aykut Soyder 0000-0002-4206-8738

Çiğdem Yenisey

Yayımlanma Tarihi 29 Eylül 2022
Gönderilme Tarihi 4 Ekim 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 6 Sayı: 3

Kaynak Göster

APA Manoğlu, B., Soyder, A., & Yenisey, Ç. (2022). Importance of Nutrition in the development of Seroma after Breast Surgery. Journal of Basic and Clinical Health Sciences, 6(3), 836-841. https://doi.org/10.30621/jbachs.1004347
AMA Manoğlu B, Soyder A, Yenisey Ç. Importance of Nutrition in the development of Seroma after Breast Surgery. JBACHS. Eylül 2022;6(3):836-841. doi:10.30621/jbachs.1004347
Chicago Manoğlu, Berke, Aykut Soyder, ve Çiğdem Yenisey. “Importance of Nutrition in the Development of Seroma After Breast Surgery”. Journal of Basic and Clinical Health Sciences 6, sy. 3 (Eylül 2022): 836-41. https://doi.org/10.30621/jbachs.1004347.
EndNote Manoğlu B, Soyder A, Yenisey Ç (01 Eylül 2022) Importance of Nutrition in the development of Seroma after Breast Surgery. Journal of Basic and Clinical Health Sciences 6 3 836–841.
IEEE B. Manoğlu, A. Soyder, ve Ç. Yenisey, “Importance of Nutrition in the development of Seroma after Breast Surgery”, JBACHS, c. 6, sy. 3, ss. 836–841, 2022, doi: 10.30621/jbachs.1004347.
ISNAD Manoğlu, Berke vd. “Importance of Nutrition in the Development of Seroma After Breast Surgery”. Journal of Basic and Clinical Health Sciences 6/3 (Eylül 2022), 836-841. https://doi.org/10.30621/jbachs.1004347.
JAMA Manoğlu B, Soyder A, Yenisey Ç. Importance of Nutrition in the development of Seroma after Breast Surgery. JBACHS. 2022;6:836–841.
MLA Manoğlu, Berke vd. “Importance of Nutrition in the Development of Seroma After Breast Surgery”. Journal of Basic and Clinical Health Sciences, c. 6, sy. 3, 2022, ss. 836-41, doi:10.30621/jbachs.1004347.
Vancouver Manoğlu B, Soyder A, Yenisey Ç. Importance of Nutrition in the development of Seroma after Breast Surgery. JBACHS. 2022;6(3):836-41.